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1

Erroneous concerns about child sexual abuse

R.Kim Oates, David P.H. Jones, David Denson, Andrew Sirotnak, Nancy Gary, Richard D. Krugman

Journal:

Child Abuse & Neglect

Year:

2000

Language:

english

File:

PDF, 46 KB

english, 2000

2

Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro

Hong Lin, Yu-Hong She, Barrie R Cassileth, Frank Sirotnak, Susanna Cunningham Rundles

Journal:

International Immunopharmacology

Year:

2004

Language:

english

File:

PDF, 277 KB

english, 2004

3

Head injury pattern in children can help differentiate accidental from non-accidental trauma

Roach, Jonathan P., Acker, Shannon N., Bensard, Denis D., Sirotnak, Andrew P., Karrer, Frederick M., Partrick, David A.

Journal:

Pediatric Surgery International

Year:

2014

Language:

english

File:

PDF, 163 KB

english, 2014

4

Parietal Pseudofracture and Spontaneous Intracranial Hemorrhage Suggesting Nonaccidental Trauma: Report of 2 Cases

Fenton, L.Z., Sirotnak, A.P., Handler, M.H.

Journal:

Pediatric Neurosurgery

Year:

2000

Language:

english

File:

PDF, 225 KB

english, 2000

5

Physical Abuse of Children

Sirotnak, A. P., Grigsby, T., Krugman, R. D.

Journal:

Pediatrics in Review

Year:

2004

Language:

english

File:

PDF, 370 KB

english, 2004

6

Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells

Jean-Marc Kühnel, Judy H. Chiao, F.M. Sirotnak

Journal:

Journal of Cellular Physiology

Year:

2000

Language:

english

File:

PDF, 199 KB

english, 2000

7

ChemInform Abstract: Synthesis and Antifolate Evaluation of the Aminopterin Analogue with a Bicyclo[2.2.2]octane Ring in Place of the Benzene Ring.

Robert C. Reynolds, Cheryl A. Johnson, James R. Piper, Frances M. Sirotnak

Journal:

Year:

2001

File:

PDF, 28 KB

2001

8

Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids

F. M. Sirotnak, C.-H. Yang, L. S. Mines, E. Oribé, J. L. Biedler

Journal:

Journal of Cellular Physiology

Year:

1986

Language:

english

File:

PDF, 1.05 MB

english, 1986

9

Altered molecular properties of tubulin in a multidrug-resistant variant of Chinese hamster cells selected for resistance to vinca alkaloids

J. Pain, F. M. Sirotnak, J. R. Barrueco, C-H. Yang, J. L. Biedler

Journal:

Journal of Cellular Physiology

Year:

1988

Language:

english

File:

PDF, 788 KB

english, 1988

10

Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin

Marcia I. Dawson, David O'Krongly, Peter D. Hobbs, Jose R. Barrueco, Frank M. Sirotnak

Journal:

Journal of Pharmaceutical Sciences

Year:

1987

Language:

english

File:

PDF, 416 KB

english, 1987

11

Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events

F.M. Sirotnak, Yuhong She, Nushmia Z. Khokhar, Paula Hayes, William Gerald, Howard I. Scher

Journal:

Molecular Carcinogenesis

Year:

2004

Language:

english

File:

PDF, 163 KB

english, 2004

12

Facile Preparation of Inside-Out Plasma Membrane Vesicles from Tumor Cells for Functional Studies of Pharmacologically Relevant Translocating ATPases

S.R. Schlemmer, F.M. Sirotnak

Journal:

Analytical Biochemistry

Year:

1995

File:

PDF, 509 KB

1995

13

Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites

James J. Kinahan, Lawrence L. Samuels, Fouad Farag, Michael P. Fanucchi, Pedro M. Vidal, Francis M. Sirotnak, Charles W. Young

Journal:

Analytical Biochemistry

Year:

1985

Language:

english

File:

PDF, 859 KB

english, 1985

14

Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring

Robert C Reynolds, Cheryl A Johnson, James R Piper, Frances M Sirotnak

Journal:

European Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 98 KB

english, 2001

15

Membrane transport and the antineoplastic action of nucleoside analogues

F. M. Sirotnak, J. R. Barrueco

Journal:

Cancer and Metastasis Reviews

Year:

1987

Language:

english

File:

PDF, 1.90 MB

english, 1987

16

Optimum scheduling during combination chemotherapy of murine leukemia

F. M. Sirotnak, F. A. Schmid, C. Temple, J. A. Montgomery

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1983

Language:

english

File:

PDF, 256 KB

english, 1983

17

New folate analogs of the 10-deaza-aminopterin series Basis for structural design and biochemical and pharmacologic properties

F. M. Sirotnak, J. I. DeGraw, D. M. Moccio, L. L. Samuels, L. J. Goutas

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1984

Language:

english

File:

PDF, 925 KB

english, 1984

18

New folate analogs of the 10-deaza-aminopterin series

F. M. Sirotnak, J. I. DeGraw, F. A. Schmid, L. J. Goutas, D. M. Moccio

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1984

Language:

english

File:

PDF, 522 KB

english, 1984

19

Quantitation of the synergistic interaction of edatrexate and cisplatin in vitro

Ting-Chao Chou, Queng-Hui Tan, Francis M. Sirotnak

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1993

Language:

english

File:

PDF, 611 KB

english, 1993

20

Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro

Ting-Chao Chou, Glenys M. Otter, Francis M. Sirotnak

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 702 KB

english, 1996

21

Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: Evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles

C. -H. Yang, M. Dembo, F. M. Sirotnak

Journal:

Journal of Membrane Biology

Year:

1983

Language:

english

File:

PDF, 1.11 MB

english, 1983

22

Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: Directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier

C. H. Yang, F. M. Sirotnak, M. Dembo

Journal:

Journal of Membrane Biology

Year:

1984

Language:

english

File:

PDF, 809 KB

english, 1984

23

Two-compartment behavior during transport of folate compounds in L1210 cell plasma membrane vesicles

C. -H. Yang, M. Dembo, F. M. Sirotnak

Journal:

Journal of Membrane Biology

Year:

1982

Language:

english

File:

PDF, 1015 KB

english, 1982

24

Effects of metabolic deprivation on methotrexate transport in L1210 leukemia cells: Further evidence for separate influx and efflux systems with different energetic requirements

M. Dembo, F. M. Sirotnak, D. M. Moccio

Journal:

Journal of Membrane Biology

Year:

1984

Language:

english

File:

PDF, 993 KB

english, 1984

25

A phase I trial of intermittent high-dose gefitinib and fixed-dose docetaxel in patients with advanced solid tumors

Matthew G. Fury, David B. Solit, Yungpo Bernard Su, Neal Rosen, F. M. Sirotnak, Robert P. Smith, Christopher G. Azzoli, Jorge E. Gomez, Vincent A. Miller, Mark G. Kris, Barbara A. Pizzo, Roxanne Henry

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2007

Language:

english

File:

PDF, 387 KB

english, 2007

26

A peptidomimetic inhibitor ofrasfunctionality markedly suppresses growth of human prostate tumor xenografts in mice. Prospects for long-term clinical utility

F. M. Sirotnak, Laura Sepp-Lorenzino, Nancy E. Kohl, Neal Rosen, Howard I. Scher

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 102 KB

english, 2000

27

A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice

F. M. Sirotnak, J. I. DeGraw, W. T. Colwell, J. R. Piper

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1998

Language:

english

File:

PDF, 162 KB

english, 1998

28

Transformation of Resistance to 8-Azaguanine in Diplococcus pneumoniae

SIROTNAK, FRANCIS M., LUNT, RAMONA B., HUTCHISON, DORRIS J.

Journal:

Year:

1960

File:

PDF, 223 KB

1960

29

Sequential Biochemical Alteration to Antifolate Resistance in L121O Leukaemia

SIROTNAK, F. M., KURITA, S., SARGENT, M. GAY, ROBINSON, D. L., HUTCHISON, DORRIS J.

Journal:

Year:

1967

File:

PDF, 263 KB

1967

30

A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non-Hodgkin's or Hodgkin's Lymphoma

O'Connor, O A, Mould, D R, Sweeney, K, Duffull, S B, Neylon, E, Hamlin, P, Horwitz, S, Sirotnak, F, Fleisher, M, Saunders, M E

Journal:

Clinical Pharmacology & Therapeutics

Year:

2009

Language:

english

File:

PDF, 275 KB

english, 2009

31

Chemical synthesis and biological activities of 5-deazaaminopterin analogs bearing substituent(s) at the 5- and/or 7-position(s)

Su, Tsann Long, Huang, Jai Tung, Chou, Ting Chao, Otter, Glenys M., Sirotnak, Francis M., Watanabe, Kyoichi A.

Journal:

Journal of Medicinal Chemistry

Year:

1988

Language:

english

File:

PDF, 916 KB

english, 1988

32

10-Propargylaminopterin and alkyl homologs of methotrexate as inhibitors of folate metabolism

Piper, J. R., McCaleb, G. S., Montgomery, J. A., Kisliuk, Roy L., Gaumont, Y., Sirotnak, F. M.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 517 KB

english, 1982

33

ChemInform Abstract: 9-Substituted Acridine Derivatives with Long Half-Life and Potent Antitumor Activity: Synthesis and Structure-Activity Relationships.

T.-L. SU, T.-C. CHOU, J. Y. KIM, J.-T. HUANG, G. CISZEWSKA, W.-Y. REN, G. M. OTTER, F. M. SIROTNAK, K. A. WATANABE

Journal:

Year:

1995

Language:

english

File:

PDF, 32 KB

english, 1995

34

ChemInform Abstract: Further Evaluation of 5-Alkyl-5-deaza Antifolates. 5-Propyl- and 5- Butyl-5-deaza Analogues of Aminopterin and Methotrexate.

J. R. PIPER, B. RAMAMURTHY, C. A. JOHNSON, J. A. MADDRY, G. M. OTTER, F. M. SIROTNAK

Journal:

Year:

1995

File:

PDF, 32 KB

1995

35

ChemInform Abstract: Analogues of 10-Deazaaminopterin and 5-Alkyl-5,10-dideazaaminopterin with the 4-Substituted 1-Naphthoyl Group in the Place of 4-Substituted Benzoyl.

J. R. PIPER, B. RAMAMURTHY, C. A. JOHNSON, G. M. OTTER, F. M. SIROTNAK

Journal:

Year:

1996

File:

PDF, 34 KB

1996

36

Synthesis and Properties of 10-Benzylaminopterin

James C. Parham, Mary Agnes Templeton, Paul L. Chello, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1979

File:

PDF, 157 KB

1979

37

Synthesis and antifolate activity of 8,10-dideazaminopterin

Joseph I. Degraw, Lawrence F. Kelly, Roy L. Kisliuk, Yvette Gaumont, Francis M. Sirotnak

Journal:

Journal of Heterocyclic Chemistry

Year:

1982

File:

PDF, 144 KB

1982

38

Pharmacokinetics of methotrexate in leukemia cells: Effect of dose and mode of injection

Jonas M. Weissbrod, Rakesh K. Jain, Francis M. Sirotnak

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1978

Language:

english

File:

PDF, 832 KB

english, 1978

39

Inflicted skeletal trauma: The relationship of perpetrators to their victims

Suzanne P. Starling, Andrew P. Sirotnak, Kurt W. Heisler, Myra L. Barnes-Eley

Journal:

Child Abuse & Neglect

Year:

2007

Language:

english

File:

PDF, 287 KB

english, 2007

40

Chromosomal Localization of the Murine RFC-1 Gene Encoding a Folate Transporter and Its Amplification in an Antifolate Resistant Variant Overproducing the Transporter

Krishnendu Roy, Judy H. Chiao, Barbara A. Spengler, Berend Tolner, Ching H. Yang, June L. Biedler, F.M. Sirotnak

Journal:

Cancer Genetics and Cytogenetics

Year:

1998

Language:

english

File:

PDF, 1.67 MB

english, 1998

41

Molecular cloning of the murine cMOAT ATPase

Friederike Fritz, Jing Chen, Paula Hayes, F.M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

2000

Language:

english

File:

PDF, 1.44 MB

english, 2000

42

Studies with ZD1839 in preclinical models

Francis M Sirotnak

Journal:

Seminars in Oncology

Year:

2003

Language:

english

File:

PDF, 247 KB

english, 2003

43

Despite some expression of folate receptor α in human mesothelioma cells, internalization of methotrexate is predominantly carrier mediated

Nushmia Z. Khokhar, Alicia F.Y. Lam, Valerie W. Rusch, F.M. Sirotnak

Journal:

The Journal of Thoracic and Cardiovascular Surgery

Year:

2002

Language:

english

File:

PDF, 1.68 MB

english, 2002

44

Markedly Decreased Binding of Vincristine to Tubulin in Vinca Alkaloid-Resistant Chinese Hamster Cells Is Associated with Selective Overexpression of α and β Tubulin Isoforms

F.M. Sirotnak, Kathleen D. Danenberg, Jing Chen, Frederike Fritz, Peter V. Danenberg

Journal:

Biochemical and Biophysical Research Communications

Year:

2000

Language:

english

File:

PDF, 62 KB

english, 2000

45

A dissociable mutant form of dihydrofolate reductase from Diplococcus pneumoniae

F.M. Sirotnak, W.A. Williams

Journal:

Archives of Biochemistry and Biophysics

Year:

1970

Language:

english

File:

PDF, 284 KB

english, 1970

46

Diydrofolate reductase from Diplococcus pneumoniae. Purification, amino acid composition, and N-terminal amino acid analysis

F.M. Sirotnak, J.S. Salser

Journal:

Archives of Biochemistry and Biophysics

Year:

1971

Language:

english

File:

PDF, 1.28 MB

english, 1971

47

Antifolate transport in L1210 leukemia cells. Kinetic evidence for the non-identity of carriers for influx and efflux

Micah Dembo, Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1976

Language:

english

File:

PDF, 670 KB

english, 1976

48

Two different effects of mutation on the binding of folate antagonists by a microbial dihydrofolate reductase

Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1973

Language:

english

File:

PDF, 641 KB

english, 1973

49

Thymidylate synthetase from Diplococcus pneumoniae properties and inhibition by folate analogs

Robert W. McCuen, Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Enzymology

Year:

1975

Language:

english

File:

PDF, 689 KB

english, 1975

50

Hyperproduction mutation in the dihydrofolate reductase gene of Diplococcus pneumoniae: Some effects on synthesis correlate with the presence of a modified enzyme form

Francis M. Sirotnak

Journal:

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis

Year:

1973

Language:

english

File:

PDF, 377 KB

english, 1973

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